Patients with immunodeficiencies and older age are at an increased risk of anal cancer. Transgenic K14E6/E7 mice with established high-grade anal dysplasia were treated topically at the anus with the protease inhibitor saquinavir (SQV) in the setting of CD4+ T-cell depletion to mimic immunodeficiency. To ensure tumor development. specific groups were treated with a topical carcinogen (7. https://www.spidertattooz.com/Creative-Grids-Quick-Trim-And-Circle-Ruler-Two-4-1-2in-x-24-1-2in-CGRMT5/